The Malaysian Thalassaemia Registry Report 2018 is a compilation of data and analysis depicting the dynamics of thalassaemia in Malaysia from 2007-2018. Thalassaemia patients were stratified and analysed according to state, centre, age, gender, ethnicity, type of disease, serum ferritin level and iron chelation treatment received. The registry provides a valuable resource of data on thalassaemia in Malaysia, and creates the foundation for future research initiatives as well as optimisation of thalassaemia care and prevention in the country.